A practical approach to assess leg muscle oxygenation during ramp-incremental cycle ergometry in heart failure

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A practical approach to assess leg muscle oxygenation during ramp-incremental cycle ergometry in heart failure

Heart failure is characterized by the inability of the cardiovascular system to maintain oxygen (O2) delivery (i.e., muscle blood flow in non-hypoxemic patients) to meet O2 demands. The resulting increase in fractional O2 extraction can be non-invasively tracked by deoxygenated hemoglobin concentration (deoxi-Hb) as measured by near-infrared spectroscopy (NIRS). We aimed to establish a simplifi...

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Oxygen uptake kinetics during incremental- and decremental-ramp cycle ergometry.

The pulmonary oxygen uptake (VO2) response to incremental-ramp cycle ergometry typically demonstrates lagged-linear first-order kinetics with a slope of ~10-11 ml·min(-1)·W(-1), both above and below the lactate threshold (θL), i.e. there is no discernible VO2 slow component (or "excess" VO2) above θL. We were interested in determining whether a reverse ramp profile would yield the same response...

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Kinetics of oxygenation in inactive forearm muscle during ramp leg cycling.

This study was carried out to determine whether hemodynamics in inactive forearm muscle during ramp leg cycling is affected from the ventilatory threshold (VT) and respiratory compensation point (RCP), at which the rate of increase in ventilation (VE) against power output begins to increase abruptly. Change in hemodynamics was evaluated by change in oxygenation index (difference between concent...

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Effects of respiratory muscle unloading on leg muscle oxygenation and blood volume during high-intensity exercise in chronic heart failure.

Blood flow requirements of the respiratory muscles (RM) increase markedly during exercise in chronic heart failure (CHF). We reasoned that if the RM could subtract a fraction of the limited cardiac output (QT) from the peripheral muscles, RM unloading would improve locomotor muscle perfusion. Nine patients with CHF (left ventricle ejection fraction = 26 +/- 7%) undertook constant-work rate test...

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Heart Failure: A Practical Approach to Treatment

Animal Physiology differs from the typical physiology textbook in that it describes the principles of physiology that underlie all animals, rather than focusing exclusively on humans. It provides a comprehensive overview of physiological systems in a wellorganized and concise manner by moving between description of general principles of physiology and specific examples of these principles from ...

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ژورنال

عنوان ژورنال: Brazilian Journal of Medical and Biological Research

سال: 2017

ISSN: 1414-431X,0100-879X

DOI: 10.1590/1414-431x20176327